Facilitating functional annotation of chicken microarray data

cDNA Microarray Data Normalization

FatiGO +: a functional profiling tool for genomic data. Integration of functional annotation, regulatory motifs and interaction data with microarray experiments

The ultimate goal of any genome-scale experiment is to provide a functional interpretation of the data, relating the available information with the hypotheses that originated the experiment. Thus, functional profiling methods have become essential in diverse scenarios such as microarray experiments, proteomics, etc. We present the FatiGO+, a web-based tool for the functional profiling of genome...

Functional Annotation of Proteomic Data from Chicken Heterophils and Macrophages Induced by Carbon Nanotube Exposure

With the expanding applications of carbon nanotubes (CNT) in biomedicine and agriculture, questions about the toxicity and biocompatibility of CNT in humans and domestic animals are becoming matters of serious concern. This study used proteomic methods to profile gene expression in chicken macrophages and heterophils in response to CNT exposure. Two-dimensional gel electrophoresis identified 12...

The importance of platform annotation in interpreting microarray data.

www.thelancet.com/oncology Vol 11 August 2010 717 Weigelt and colleagues recently compared three methods for classifying breast cancers into molecular subtypes. Aside from an obvious question of whether they should have centred each gene, an issue previously discussed in the context of classifying breast-cancer subtypes, there is concern that insuffi cient attention has been paid to the annotat...

Ontology-based Annotation and Query of Tissue Microarray Data

The Stanford Tissue Microarray Database (TMAD) is a repository of data amassed by a consortium of pathologists and biomedical researchers. The TMAD data are annotated with multiple free-text fields, specifying the pathological diagnoses for each tissue sample. These annotations are spread out over multiple text fields and are not structured according to any ontology, making it difficult to inte...